刘  格 副研究员

海洋微生物活性物质的发掘和利用
研究方向: 海洋微生物活性物质的发掘和利用
岗  位: 副研究员
部  门: 实验海洋生物学重点实验室
联系方式: 0532-82898648
电子邮件: liuge@qdio.ac.cn
个人网页:

理学博士,主要从事海洋微生物活性物质的发掘及利用工作,包括海洋微生物的分离培养及抗肿瘤海洋微生物活性多糖的机理阐释等研究工作。目前共发表一作SCI研究论文10篇,包括生物学领域的专业杂志Journal of Biological Chemistry, Cell Death & Disease, FASEB Journal 等。作为项目负责人承担了国家自然科学基金青年项目、山东省自然科学基金博士项目等多项课题。

教育经历

● 2015-09 至 2018-06, 中国科学院海洋研究所, 海洋生物学, 博士

● 2011-09 至 2014-06, 中国科学院海洋研究所, 海洋药物学, 硕士

● 2007-09 至 2011-06, 东北师范大学, 生物技术, 学士

工作经历

● 2023.10至今,中国科学院海洋研究所,实验海洋生物学重点实验室,副研究员

● 2020.08-2023.09,中国科学院海洋研究所,实验海洋生物学重点实验室,助理研究员

● 2018.08-2020.07,中国科学院海洋研究所,实验海洋生物学重点实验室,博士后

主持或参加主要科研项目情况

1.青岛海洋科学与技术试点国家实验室,“十四五”重大项目子课题,2022QNLM 030004-3,深海难培养微生物的分离培养及特殊生命过程研究,2022/05-2025/4,主持

2. 国家自然科学基金青年项目,42006081,海洋细菌胞外多糖EPS11靶向I型胶原蛋白抑制肝癌转移的机制研究,2021/01-2023/12,主持

3. 山东省自然科学基金,博士项目,ZR2019BH024, 深海细菌胞外多糖EPS364的抗肝癌作用机制研究,2019/07-2022/06,主持

发表的代表性文章(限10篇)

1. Ge Liu; Rui Liu; Yeqi Shan; Chaomin Sun; Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I, Journal of Biological Chemistry, 2021, 297(4): 101133 

2. Ge Liu; Yeqi Shan; Rikuan Zheng; Rui Liu; Chaomin Sun; Growth promotion of a deep-sea bacterium by sensing infrared light through a bacteriophytochrome photoreceptor, Environmental Microbiology, 2021, 23(8): 4466-4477

3. Ge Liu; Shan Kuang; Ruobing Cao; Ju Wang; Quancai Peng; Chaomin Sun; Sorafenib kills Huh7.5 liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via ATP-AMPK-mTOR-SREBP1 signaling pathway, FASEB Journal, 2019, 33(9): 10089-10103

4. Ge Liu; Kai Wang; Shan Kuang; Ruobing Cao; Li Bao; Rui Liu; Hongwei Liu; Chaomin Sun; The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death, Cell Death & Disease, 2018, 9(6): 689

5. Ge Liu#; Yeqi Shan#; Rui Liu; Chaomin Sun ; Insights into the bacterial and archaeal population dynamics in the deep-sea hydrothermal sediments exposed to lights with different wavelengths, Deep-Sea Research Part I, 2023, 195: 103996

6. Yun Wang#; Ge Liu#; Rui Liu; Maosheng Wei; Jinxiang Zhang; Chaomin Sun; EPS364, a novel deep-sea bacterial exopolysaccharide, inhibits liver cancer cell growth and adhesion, Marine Drugs,2021, 19(3): 171

7.  Ge Liu, Shan Kuang, Shimei Wu, Weihua Jin, Chaomin Sun; A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo. Scientific Reports, 2016, 6(26722).

8. Ge Liu, Shimei Wu, Weihua Jin, Chaomin Sun; Amy63, a novel type of marine  bacterial  multifunctional  enzyme  possessing  amylase,  agarase  and carrageenase  activities.  Scientific  reports,  2016.01.04,  6:18726.

9.  Xin Qi#, Ge Liu#, Lin Qiu,Xiukun Lin, Ming Liu; Marine bromophenol bis (2,3- dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems. Biomedicine & Pharmacotherapy,2015,75:58-66.

10. Ge Liu, Ming Liu, Jianteng Wei, Haijuan Huang, Yuyan Zhang, Jin Zhao, Lin Xiao, Ning Wu, Lanhong Zheng, Xiukun Lin; CS5931, a novel polypeptide in Ciona savignyi, represses angiogenesis via inhibiting vascular endothelial growth factor (VEGF) and matrix Metalloproteinases (MMPs). Marine Drugs, 2014, 12(3), 1530-1544.